Single Nucleotide Polymorphism and Breast Cancer

Available online http:// mamilla-cancer-research.com/ sum/8/4/108 Commentary wiz nucleotide polymorphisms and breast cancer: not yet a succeeder story Rulla M Tamimi Channing Laboratory, surgical incision of Medicine, Brigham and Womens Hospital and Harvard Medical School, and De disassemblement of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA alike(p) author: Rulla Tamimi, rulla.tamimi@channing.harvard.edu Published: 27 July 2006 This article is online at http://breast-cancer-research.com/content/8/4/108 © 2006 BioMed Central Ltd Breast Cancer seek 2006, 8:108 (doi:10.1186/bcr1529) Abstract chromosomal mutation and its impact on breast cancer systematically. Numerous studies study examined first set up penetrance susceptibility polymorphisms in prospect genes, with some reporting solid findings. However, for the most part these tie-ins could not be replicated in later(prenominal) studies, suggesting that the pilot burner observations were due to chance [5]. In a pooled analysis of 46 connector studies examining polymorphisms in 18 different genes, only trinity polymorphisms were significantly associated with breast cancer [5].

Despite considerable efforts make during the other(prenominal) few years to study genetic variation and breast cancer, on that point has been little success in identifying alpha contributions to breast cancer. The inadequacy of robust and consistent findings from single SNP association studies led to the effusion of haplotype studies, which promised to examine more comprehensively the association between harsh genetic variation in view genes and ! risk for disease. This latest direction of research efforts has also been roughly disappointing. Numerous studies have examined low penetrance susceptibility polymorphisms in candidate genes, with some reporting significant findings. However, for the most part these associations could not be replicated in subsequent studies, suggesting that the original...If you want to get a full essay, order it on our website: BestEssayCheap.com

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